INTRODUCTION
Crinodef contains Deflazacort which belongs to class of medicines called corticosteroids. It is a glucocorticoid which is used as an anti-inflammatory and immunosuppressant. Glucocorticoids works by inhibiting the inflammatory signaling pathways and inflammatory gene expression that cause inflammation and also suppress immunity or reduce the strength of the body’s immune system. It is used to treat inflammation including the asthma, arthritis and allergies. It is also used to treat Duchenne muscular dystrophy (DMD) in patients 2 years of age and older. Duchenne muscular dystrophy (DMD) is a severe type of muscular dystrophy that primarily affects boys.
The recommended daily dosage is approximately 0.9 mg/kg/day administered orally. This medicine is not recommended for use in pregnant, or if you are trying to become pregnant. Consult your doctor for advice. Do not drive or operate any machinery while taking this medicine, it may make you feel dizzy. The most common side effects include dyspepsia and peptic ulcer, weight increase, increased appetite, upper respiratory tract infection, cough, nausea and headache.
USES OF Crinodef
- Treat inflammation including asthma, arthritis and allergies
- Treat Duchenne muscular dystrophy (DMD) in patients 2 years of age and older
- Suppress the immune system in transplant operations
HOW Crinodef WORKS
Crinodef works by inhibiting the inflammatory signaling pathways and inflammatory gene expression that cause inflammation and also suppress immunity or reduce the strength of the body’s immune system.
DIRECTIONS FOR USE
Always take Crinodef exactly as prescribed by your doctor. Swallow the medicine whole with plenty of water.
SIDE EFFECTS OF Crinodef
SERIOUS
- Mental health problem
- Feeling depressed, including thinking about suicide
- Black tarry stools or clotted blood in your stools (faeces)
COMMON
- Dyspepsia and peptic ulcer
- Weight increased
- Increased appetite
- Upper respiratory tract infection
- Cough
- Nausea
- Headache
RARE
- Bleeding under the skin, redness
- General muscle weakness or tiredness
HOW TO MANAGE SIDE EFFECTS
Nausea:
Keep try taking this medicine with, or just after, a meal or snack and stick to simple meals and do not eat rich or spicy food.
Headache:
Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.
WARNING & PRECAUTIONS
PREGNANCY
Crinodef is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
BREASTFEEDING
Crinodef is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
DRIVING AND USING MACHINES
Do not drive or operate any machinery while taking this medicine, it may make you feel dizzy.
ALCOHOL
Consumption of alcohol is not recommended during treatment with this medicine.
KIDNEY
Crinodef should be taken with caution in patients with severe kidney disease. Consult your doctor for advice.
LIVER
Crinodef should be taken with caution in patients with severe liver disease. Consult your doctor for advice.
ALLERGY
Do not take if you are allergic to the medicine.
HEART DISEASE
If you have any heart related problems, consult your doctor for advice before taking this medicine.
OTHERS
Do not take Crinodef if you have or ever had mental problems such as depression or psychoses.
INTERACTIONS
Talk to your doctor if you are taking:
- Medicines used to treat the skin and fungal infections (rifampicin, rifabutin, carbamazepine, phenobarbitone, phenytoin, primidone)
- Medicines used to treat the bacterial infections (telithromycin, rifampicin and ciprofloxacin)
- Ketoconazole it may possible to reduce the maintenance dose of deflazacort
SYNOPSIS
| Drug | : | Deflazacort |
| Pharmacological Category | : | Steroid medicine called glucocorticoid |
| Therapeutic Indication | : | Duchenne muscular dystrophy |
| Dosage Forms | : | Tablet, Oral suspension |
MORE INFORMATION
Store at room temperature 15-25°C and keep out of reach of children.
FAQs ABOUT Crinodef
Can Crinodef be used in pregnant women?
No. It is not recommended for use in the pregnant women. Consult your doctor before taking.
Is Crinodef a steroid?
Crinodef is a steroid medicine called glucocorticoids. These corticosteroids occur naturally in the body and help to maintain health and wellbeing.
What is Crinodef used for?
It is used to treat Duchenne muscular dystrophy (DMD; a progressive disease in which the muscles do not function properly) in adults and children 2 years of age and older.